The influence with the variant on RNA or protein function, depending on experimental evidence from submitters.
This worth is calculated by NCBI according to information from submitters. Read our rules for calculating the evaluate standing. The number of submissions which lead to this evaluation position is proven in parentheses.
This date signifies the final time this VCV history was updated. The update could be due to an update to one of several involved submitted documents (SCVs), or because of an update that ClinVar created to your variant which include introducing HGVS expressions or perhaps a rs quantity.
This column consists of more info supporting the classification, which include citations, the comment on classification, and detailed evidence provided as observations of your variant because of the submitter.
The problem for the classification, provided by the submitter for this submitted (SCV) record. This column also features the impacted position and allele origin of individuals observed using this type of variant.
The internet site is secure. The https:// assures that you'll be connecting towards the official Internet site Which any information and facts you offer is encrypted and transmitted securely.
There aren't any citations for germline classification of this variant in ClinVar. If you understand of citations for this variation, remember to take into account distributing that details to ClinVar.
The amount of variants in ClinVar which are contained within this gene, which has a url to check out the listing of variants.
This Web site is using a protection provider to protect itself from on the web assaults. thr777 The action you merely performed triggered the security Remedy. There are several steps that may cause this block like distributing a particular word or phrase, a SQL command or malformed information.
The location is safe. The https:// assures that you're connecting towards the Formal Web-site and that any details you supply is encrypted and transmitted securely.
Stars symbolize the aggregate evaluate standing, or the level of critique supporting the mixture germline classification for this VCV record.
The positioning is protected. The https:// guarantees that you will be connecting towards the official Web page Which any facts you deliver is encrypted and transmitted securely.
The positioning is safe. The https:// makes certain you are connecting on the Formal website and that any details you give is encrypted and transmitted securely.
Stars stand for the evaluate position, or the level of assessment supporting the submitted (SCV) document. This value is calculated by NCBI according to knowledge from the submitter.